About Us

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Summary:

SentryDx is a cancer diagnostic company. Our test will save lives by accurately diagnosing residual cancer earlier than the current standard of care using a blood draw, called a liquid biopsy. 

SentryDx has developed a patent pending technology for accurately diagnosing cancer recurrence using Liquid Biopsy and Passive Enrichment, a process we call Bicycle PCR. Two-cycles Allows for internal process control. Our goal is to get regulatory approval for our highly accurate method of detecting low-frequency cancer mutations from a blood draw.

Q & A:

How is SentryDx different?

• All major competitors first "look for" cancer DNA. SentryDx first "looks for" normal DNA. 

How does SentryDx "look for" normal DNA?

• SentryDx uses a blocker which targets normal DNA. Cancer DNA is rare, like finding a needle in a haystack. By blocking normal DNA first, SentryDx can turn a needle in a haystack into a mountain of needles. 

What is the advantage of a blocker?

• Near perfect accuracy by eliminating problems associated with DNA base pair mismatch and variant dropout. 
• A blocker also reduces the amount of sequencing required because cancer DNA is no longer rare. Competitors require >100,000 reads, where SentryDx only needs 100 reads greatly lowing the cost of for sequencing. 

What is the accuracy of SentryDx?

• SentryDx can deliver high sensitivity and high specificity at the same time, providing near perfect results for the absence/presence determination of cancer DNA. 

What is the sensitivity of SentryDx?

• SentryDx can accurately detect a single copy of cancer DNA. SentryDx can reliably detect a sample with 0.01% cancer using genomic DNA. 
• SentryDx is Best in Class for Specificity with NO false positives and Limit of Detection (LoD). 

What is the specificity of SentryDx?

• SentryDx should have a specificity near 100% while maintaining a sensitivity of 0.01%

Are the SentryDx process results quantifiable? 

• YES!

Can the SentryDx process be approved by the FDA?

• Since the SentryDx process is standardized, we believe we have a path to FDA approval. 

What instruments are required for the SentryDx process?

• SentryDx uses a standard thermal cycler and Sanger sequencing which will reduce the cost to 1/10th the cost of others.